No. 8 Serena Williams (USA) vs. Maria Sharapova (RUS)
7 p.m. in Arthur Ashe Stadium
- The first-ever US Open meeting between Williams and Sharapova will double as their 22rd career WTA match. The American has dominated the head-to-head, coming in with a 19-2 advantage over her Round 1 opponent.
- Both women have been champions in New York. Serena is a six-time US Open women's singles winner, most recently in 2014, while Sharapova claimed the title in 2006.
- One year after falling to Naomi Osaka in the 2019 final, Serena returns to New York seeking to match Margaret Court's all-time record of 24 Grand Slam singles titles.
